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BACE-2 Inhibitor
- BACE2 Inhibitor 3l
Axon 2957
CAS:
1676107-08-6
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C36H38F3N3O3
- MW: 617.7
Description
Potent and highly selective human β-secretase 2 (BACE-2) inhibitor with a Ki value of 1.6 nM and >500-fold selectivity over BACE-1.
More Information
| Parent CAS No. | 1676107-08-6 |
|---|---|
| Chemical Name | N1-((2S,3R)-3-Hydroxy-1-phenyl-4-(3-(trifluoromethyl)benzylamino)butan-2-yl)-N3,5-dimethyl-N3-((R)-1-phenylethyl)isophthalamide |
| SMILES | C1C(C)=CC(C(=O)N[C@@H](CC2C=CC=CC=2)[C@H](O)CNCC2C=CC=C(C(F)(F)F)C=2)=CC=1C(=O)N(C)[C@@H](C1C=CC=CC=1)C |&1:8,16,37,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C36H38F3N3O3/c1-24-17-29(21-30(18-24)35(45)42(3)25(2)28-14-8-5-9-15-28)34(44)41-32(20-26-11-6-4-7-12-26)33(43)23-40-22-27-13-10-16-31(19-27)36(37,38)39/h4-19,21,25,32-33,40,43H,20,22-23H2,1-3H3,(H,41,44)/t25-,32+,33-/m1/s1 |
| InChiKey | KQGVKXJLEHXBDS-CBHGIOBQSA-N |
| CID | 117961403 |
| Short Description | BACE 2 inhibitor |
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