JTP 1048196

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2947

CAS [55377-56-5]

MF C17H14O4
MW 282.29

  • Purity: 99%
  • Soluble in DMSO
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JTP 1048196

Description

JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 (Axon 2939) which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels.

KEYWORDS: JTP 1048196 | supplier | LUBAC inhibitor | JTP1048196 | JTP-1048196 | CAS [55377-56-5] | NF-κB Pathway | Ubiquitin Ligase (E3; LUBAC) | Inhibitor | Enzymes | HOIL-1L | HOIP | SHARPIN

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10 mg €125.00 In Stock
50 mg €375.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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