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JTP 1048196
- Soluble in DMSO
- MF: C17H14O4
- MW: 282.29
Description
JTP 1048196 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value of 16.1 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex. The lactone structure of JTP 1048196 was transformed to the reactive α,β-unsaturated carbonyl moiety JTP 0819958 (Axon 2939) which reacts with the cysteine residue of LUBAC, leading to its covalent inhibition in vitro and cellular levels.
More Information
| Parent CAS No. | 55377-56-5 |
|---|---|
| Chemical Name | 3-(2-(2-Methoxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one |
| SMILES | C1C=C2C(=O)OC(CC(=O)C3C=CC=CC=3OC)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14O4/c1-20-15-9-5-4-8-13(15)14(18)10-16-11-6-2-3-7-12(11)17(19)21-16/h2-9,16H,10H2,1H3 |
| InChiKey | DFBPFCSPQHHVSO-UHFFFAOYSA-N |
| CID | 4889633 |
| Short Description | LUBAC inhibitor |
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