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TH 5487

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2934

CAS [2304947-71-3]

MF C19H18BrIN4O2
MW 541.18

  • Purity: 98%
  • Soluble in DMSO

TH 5487

Description

TH 5487 is a potent and selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with an IC50 of 342 nM. TH 5487 inhibited DNA repair and modified OGG1 chromatin dynamics, which resulted in the inhibition of proinflammatory pathway genes. Furthermore, TH 5487 was well tolerated by mice and suppressed lipopolysaccharide- and tumor necrosis factor–α–mediated neutrophilic inflammation in the lungs.

KEYWORDS: TH 5487 | supplier | OGG1 inhibitor | TH5487 | TH-5487 | CAS [2304947-71-3] | Glycosides | OGG1 | Inhibitor | Enzymes

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10 mg €125.00 In Stock
50 mg €435.00 In Stock
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2 x 10 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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