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(+)-Kifunensine
- FR 900494
Axon 1730
CAS:
109944-15-2
Purity:
99%
- Soluble in water and DMSO
- MF: C8H12N2O6
- MW: 232.19
Description
(+)-Kifunensine is a potent class I α-mannosidase inhibitor that disrupts glycoprotein biosynthesis and N-glycan processing.
Kifunensine inhibits human ER α-mannosidase I and Golgi class I mannosidase with reported Ki values of 130 nM and 23 nM, respectively. It is used to study glycosylation, protein quality control and high-mannose glycoprotein production.
Key Features
- Potent inhibitor of class I α-mannosidases
- Ki: 130 nM for ER α-mannosidase I
- Ki: 23 nM for Golgi class I mannosidase
- Modulates N-glycan processing and glycoprotein biosynthesis
Applications
- Glycoprotein biosynthesis research
- N-glycosylation pathway studies
- ER/Golgi protein processing assays
- Biotherapeutic glycoform engineering models
More Information
| Parent CAS No. | 109944-15-2 |
|---|---|
| Chemical Name | (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)tetrahydroimidazo[1,2-a]pyridine-2,3(1H,5H)-dione |
| MFCD | MFCD00270017 |
| Short Description | α-Mannosidase inhibitor |
(+)-Kifunensine
potent inhibitor of class I α-mannosidases
FR 900494
Kifunensine
FR900494
class I α-mannosidases
Inhibitor
Glycoprotein biosynthesis research
N-glycosylation pathway studies
ER/Golgi protein processing assays
Biotherapeutic glycoform engineering models
enzyme pharmacology
drug discovery
CAS 109944-15-2
Axon Medchem
Axon 1730
Supplier
Vendor
References
- H Kayakiri et al. Structure of kifunensine, a new immunomodulator isolated from an actinomycete. J. Org. Chem. 1989, 54(17), 4015-4016.
- AD Elbein et al. Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J. Biol. Chem. 1990, 265(26), 15599-15605.
- KW Hering et al. A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum alpha-mannosidase I. J Org Chem. 2005, 70(24), 9892-9904.
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