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Nucleozin
- Soluble in DMSO
- MF: C21H19ClN4O4
- MW: 426.85
Description
Nucleozin triggers the aggregation of influenza A nucleoprotein and inhibits its nuclear accumulation. Nucleozin inhibited infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 values of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assays, respectively. Also, nucleozin protected mice challenged with lethal doses of avian influenza A H5N1.
More Information
| Parent CAS No. | 341001-38-5 |
|---|---|
| Chemical Name | (4-(2-Chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenylisoxazol-4-yl)methanone |
| SMILES | O1N=C(C2C=CC=CC=2)C(C(=O)N2CCN(C3C=CC([N+]([O-])=O)=CC=3Cl)CC2)=C1C |
| MFCD | MFCD01426660 |
| InChi | InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3 |
| InChiKey | OWXBJAPOSQSWAO-UHFFFAOYSA-N |
| CID | 2863945 |
| Short Description | Antiviral agent |
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