Nucleozin triggers the aggregation of influenza A nucleoprotein and inhibits its nuclear accumulation. Nucleozin inhibited infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 values of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assays, respectively. Also, nucleozin protected mice challenged with lethal doses of avian influenza A H5N1.

KEYWORDS: Nucleozin | supplier | Antiviral agent | CAS [341001-38-5] | DNA-RNA | Nucleoprotein | Inhibitor | Proteins | Influenza A