The genomes of all negative-strand RNA viruses are coated by the viral nucleoprotein (NP). Together with the viral RNA-dependent RNA polymerase, these ribonucleoprotein complexes form the minimal functional unit for all viral transcription and replication[1]. Influenza NP is the most abundantly expressed protein during the course of infection with multiple functionalities. NP accumulates in the nucleus in the early phases of infection and is exclusively distributed in cytoplasm later during viral assembly and maturation. Influenza A nucleoprotein is identified as an antiviral target[2].