DRI-C21045

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2887

CAS [2101765-81-3]

MF C32H24N2O7S
MW 580.61

  • Purity: 98%
  • Soluble in DMSO

DRI-C21045

Description

DRI-C21045 is an inhibitor of the CD40-CD40L costimulatory protein-protein interaction with an IC50 value of 0.17 µM. Moreover, the activity of DRI-C21045 (IC50) in the low micromolar range has been confirmed in cell assays including inhibition of CD40L-induced activation in NF-κB sensor cells, THP-1 myeloid cells, and primary human B cells as well as in murine allogeneic skin transplant and alloantigen-induced T cell expansion in draining lymph node experiments.

KEYWORDS: DRI-C21045 | supplier | CD40–CD40L inhibitor | DRI C21045 | DRIC21045 | CAS [2101765-81-3] | TNF-α | CD40 | Inhibitor | Receptors | Immunomodulation | NF-κB | THP-1 | B cell | T cell | TNF-TNFR

Inhibitor of the CD40-CD40L costimulatory protein-protein interaction

Chemical name

8-(4'-(4-(Methoxycarbonyl)benzamido)biphenyl-4-ylcarboxamido)naphthalene-1-sulfonic acid

Parent CAS No.

[2101765-81-3]

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10 mg €125.00 In Stock
50 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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