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Axon 2887
CAS [2101765-81-3]
MF C32H24N2O7SMW 580.61
DRI-C21045 is an inhibitor of the CD40-CD40L costimulatory protein-protein interaction with an IC50 value of 0.17 µM. Moreover, the activity of DRI-C21045 (IC50) in the low micromolar range has been confirmed in cell assays including inhibition of CD40L-induced activation in NF-κB sensor cells, THP-1 myeloid cells, and primary human B cells as well as in murine allogeneic skin transplant and alloantigen-induced T cell expansion in draining lymph node experiments.
KEYWORDS: DRI-C21045 | supplier | CD40–CD40L inhibitor | DRI C21045 | DRIC21045 | CAS [2101765-81-3] | TNF-α | CD40 | Inhibitor | Receptors | Immunomodulation | NF-κB | THP-1 | B cell | T cell | TNF-TNFR
8-(4'-(4-(Methoxycarbonyl)benzamido)biphenyl-4-ylcarboxamido)naphthalene-1-sulfonic acid
[2101765-81-3]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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