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ML 221
Axon 2870
CAS:
877636-42-5
Purity:
99%
- Soluble in DMSO
- MF: C17H11N3O6S
- MW: 385.35
Description
Potent apelin (APJ) receptor functional antagonist in cell-based assays (IC50 value is 1.75 µM). ML 221 is >37-fold selective over the closely related angiotensin II type 1 (AT-1) receptor.
More Information
| Parent CAS No. | 877636-42-5 |
|---|---|
| Chemical Name | 4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate |
| SMILES | C1C=C(C(=O)OC2=COC(CSC3N=CC=CN=3)=CC2=O)C=CC=1[N+]([O-])=O |
| MFCD | N.A. |
| InChi | InChI=1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2 |
| InChiKey | UASIRTUMPRQVFY-UHFFFAOYSA-N |
| CID | 7217941 |
| Short Description | APJ antagonist |
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