NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax.

KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax