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NS 1619
- Soluble in DMSO
- MF: C15H8F6N2O2
- MW: 362.23
Description
NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax.
More Information
| Parent CAS No. | 153587-01-0 |
|---|---|
| Chemical Name | 1-(2-Hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one |
| SMILES | C1(C(F)(F)F)C=C2NC(=O)N(C3C(O)=CC=C(C(F)(F)F)C=3)C2=CC=1 |
| MFCD | MFCD00928190 |
| InChi | InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) |
| InChiKey | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
| CID | 4552 |
| Short Description | BK channel activator |
References
- SP Olesen et al. Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur J Pharmacol. 1994 Jan 4;251(1):53-9.
- G Debska et al. Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem Pharmacol. 2003 Jun 1;65(11):1827-34.
- X Han et al. The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem Biophys Res Commun. 2008 Oct 17;375(2):205-9.
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