NS 1619

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2854

CAS [153587-01-0]

MF C15H8F6N2O2
MW 362.23

  • Purity: 98%
  • Soluble in DMSO

NS 1619


NS 1619 is a selective large-conductance Ca2+-activated K+ channel (BK channel) activator which decreased the mitochondrial membrane potential with an EC50 value of 3.6 μM. Besides induction of apoptosis, NS 1619 inhibits both mitochondrial function in the glioma cell line LN229, as well as proliferation of A2780 cells (IC50 value of 31.1 μM). These anticancer activities are associated with increased expression of p53, p21, and Bax.

KEYWORDS: NS 1619 | supplier | BK channel activator | NS1619 | NS-1619 | CAS [153587-01-0] | Potassium | KCa1.1 | Opener | Ion Channels | Apoptosis | Glioma | A2780 | p53 | p21 | Bax

Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €325.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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