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LB-100
- LB-1
Axon 2820
CAS:
1632032-53-1
Purity:
99%
- Soluble in water and DMSO
- MF: C13H20N2O4
- MW: 268.31
Description
LB-100 is a specific competitive inhibitor of PP2A. In a mouse xenograft model of human pancreatic cancer, LB-100 produced significant radiosensitization with minimal weight loss. Furthermore, LB-100 decreased cell viability through caspase activation and G2/M cell-cycle arrest. LB100 enhanced daunorubicin cytotoxicity resulting in decreased xenograft volumes and improved overall survival.
More Information
| Parent CAS No. | 1632032-53-1 |
|---|---|
| Chemical Name | 3-(4-Methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
| SMILES | C1C2OC(C(C(=O)N3CCN(C)CC3)C2C(O)=O)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H,2-7H2,1H3,(H,17,18) |
| InChiKey | JUQMLSGOTNKJKI-UHFFFAOYSA-N |
| CID | 3578572 |
| Short Description | PP2A inhibitor |
References
- D Wei et al. Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair. Clin Cancer Res. 2013 Aug 15;19(16):4422-32.
- C Hu et al. PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation. Sci Rep. 2017 Jun 6;7(1):2894.
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