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TD52
Axon 2700
CAS:
1798328-24-1
Purity:
99%
- Soluble in DMSO
- MF: C24H16N4
- MW: 360.41
Description
The CIP2A inhibitor TD52 had more potent apoptotic effects than erlotinib (Axon 1128) in HCC cells (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). Also, CIP2A-dependent p-Akt downregulation mediates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo.
More Information
| Parent CAS No. | 1798328-24-1 |
|---|---|
| Chemical Name | N2,N3-Bis(3-ethynylphenyl)quinoxaline-2,3-diamine |
| SMILES | C1C=C2N=C(NC3C=CC=C(C#C)C=3)C(NC3C=C(C#C)C=CC=3)=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H16N4/c1-3-17-9-7-11-19(15-17)25-23-24(26-20-12-8-10-18(4-2)16-20)28-22-14-6-5-13-21(22)27-23/h1-2,5-16H,(H,25,27)(H,26,28) |
| InChiKey | SCUPZFSEJFWQIS-UHFFFAOYSA-N |
| CID | 118656842 |
| Short Description | CIP2A inhibitor |
References
- HC Yu et al. Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A. Cell Death Dis. 2014 Jul 31;5:e1359.
- CY Liu et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.
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