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BPKDi
Axon 2798
CAS:
1201673-28-0
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H28N6O
- MW: 380.49
Description
BPKDi is an inhibitor of protein kinase D (IC50 values of 1, 9, and 1 nM for PKD1, PKD2 and PKD3, respectively). BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells.
More Information
| Parent CAS No. | 1201673-28-0 |
|---|---|
| Chemical Name | 2'-(Cyclohexylamino)-6-(piperazin-1-yl)-2,4'-bipyridine-4-carboxamide |
| MFCD | N.A, |
| Short Description | PKD inhibitor |
References
- L Monovich et al. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 2010 Feb 5;584(3):631-7
- EL Meredith et al. Identification of potent and selective amidobipyridyl inhibitors of protein kinase D. J Med Chem. 2010 Aug 12;53(15):5422-38.
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