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AR 420626
Axon 2794
CAS:
1798310-55-0
Purity:
99%
- Soluble in DMSO
- MF: C21H18Cl2N2O3
- MW: 417.29
Description
AR 420626 is an allosteric FFA3 (GPR41) receptor agonist (pEC50 value of 5.74) which enhances mucosal defenses and prevents NSAID-induced enteropathy via the GLP-2 pathway in rats.
More Information
| Parent CAS No. | 1798310-55-0 |
|---|---|
| Chemical Name | N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide |
| SMILES | C1CC2NC(C)=C(C(=O)NC3C=C(Cl)C=CC=3Cl)C(C3=CC=CO3)C=2C(=O)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27) |
| InChiKey | GGTYQECCGLBHGS-UHFFFAOYSA-N |
| CID | 91885415 |
| Short Description | GPR41 agonist |
References
- BD Hudson et al. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 2014 Aug;86(2):200-10.
- H Said et al. FFA3 Activation Stimulates Duodenal Bicarbonate Secretion and Prevents NSAID-Induced Enteropathy via the GLP-2 Pathway in Rats. Dig Dis Sci. 2017 Aug;62(8):1944-1952.
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