XMD 8-87

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2762

CAS [1234480-46-6]

MF C24H27N7O2
MW 445.52

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

XMD 8-87

Description

XMD 8-87 is a potent and selective inhibitor of Ack1 (activated CDC42-associated kinase) also known as tyrosine kinase nonreceptor 2 (TNK2). XMD8-87 has IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.

JE Maxson et al. Development and Repurposing of Small-Molecule Kinase Inhibitors to Target Novel Leukemogenic TNK2 Mutations. Blood 2014 124:435.

JE Maxson et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. Cancer Res. 2016 Jan 1;76(1):127-38.

Potent and selective inhibitor of Ack1 tyrosine kinase (also known as TNK2)

Chemical name

2-(2-Methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one

Parent CAS No.

[1234480-46-6]

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5 mg	€95.00	In Stock
25 mg	€325.00	In Stock

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2031	AIM 100	Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2)		€95.00
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XMD 8-87

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XMD 8-87

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