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AIM 100
Axon 2031
CAS:
873305-35-2
- Optical Purity: 98.1% e.e.
- Soluble in DMSO
- MF: C23H21N3O2
- MW: 371.43
Description
AIM 100 is a selective Ack1/TNK2 tyrosine kinase inhibitor. It inhibits Ack1 activity and suppresses Ack1-dependent androgen receptor Tyr267 phosphorylation and recruitment to the ATM enhancer.
Ack1 links receptor tyrosine kinase inputs to androgen receptor signaling, survival pathways and transcriptional regulation in cancer models. AIM 100 is useful for studying Ack1/AR/ATM signaling and TNK2-dependent oncogenic pathway biology.
Key Features
- Selective Ack1/TNK2 inhibitor
- Blocks Ack1-dependent AR Tyr267 phosphorylation
- Modulates Ack1/AR/ATM signaling
- Relevant to prostate cancer pathway research
Applications
- Ack1 kinase assays
- Androgen receptor phosphorylation studies
- Prostate cancer signaling models
- TNK2 pathway inhibitor profiling
More Information
| Parent CAS No. | 873305-35-2 |
|---|---|
| Chemical Name | (S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine |
| SMILES | C1=NC(NC[C@@H]2CCCO2)=C2C(C3=CC=CC=C3)=C(C3=CC=CC=C3)OC2=N1 |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6,8-11,15,18H,7,12-14H2,(H,24,25,26)/t18-/m0/s1 |
| InChiKey | XNFHHOXCDUAYSR-SFHVURJKSA-N |
| CID | 11501591 |
| Short Description | Ack1 inhibitor |
References
- K Mahajan et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010, 70(12), 1274-1285.
- K Mahajan et al. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. J. Biol. Chem. 2012, 287(26), 22112-22122.
- K Mahajan, NP Mahajan. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J. Cell. Physiol. 2010, 224, 327–333.
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