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T56-LIMKi

 - T5601640
Axon 2721
CAS:  924473-59-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C19H14F3N3O3
  • MW:  389.33

Description

T56-LIMKi (T5601640) is a cell-active inhibitor of LIM kinase 2 (LIMK2) that reduces phosphorylation of the actin-regulatory protein cofilin. It inhibits proliferation of NF1-deficient MEFs and ST88-14, U87 and Panc-1 cells with reported IC50 values of 30, 18, 7 and 35 µM, respectively.

By suppressing the LIMK2–cofilin axis, T56-LIMKi is used to investigate cytoskeletal remodeling, proliferation and tumor-cell behavior. In Panc-1 xenograft studies it reduced tumor size together with intratumoral phospho-cofilin, providing an in vivo pharmacodynamic readout of LIMK pathway inhibition.

Key Features

  • Cell-active LIMK2 inhibitor
  • Reduces cofilin phosphorylation
  • Micromolar antiproliferative activity in several cell models
  • Demonstrates in vivo pathway engagement

Applications

  • LIMK2 signaling research
  • Cofilin phosphorylation assays
  • Actin-cytoskeleton studies
  • NF1-deficient cell models
  • Glioma, schwannoma and pancreatic cancer research

More Information

Certificate of Analysis (B1)
Material Safety Data Sheet (B1)

Certificate of Analysis

B2

Material Safety Data Sheet

B2
Parent CAS No. 924473-59-6
Chemical Name 3-Methyl-N-(3-(3-(trifluoromethyl)phenylcarbamoyl)phenyl)isoxazole-5-carboxamide
SMILES C1C=CC(C(=O)NC2C=CC=C(C(F)(F)F)C=2)=CC=1NC(=O)C1=CC(C)=NO1
MFCD MFCD08495674
InChi InChI=1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27)
InChiKey XVOKFRPKSAWELK-UHFFFAOYSA-N
CID 9438169
Short Description LIMK2 inhibitor

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