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LIMK1 inhibitor BMS4

 - BMS4
Axon 1949
CAS:  905298-84-2
Purity:  99%
  • Soluble in DMSO
  • MF:  C23H23N7O2S
  • MW:  461.54

Description

LIMK1 inhibitor BMS4 is a potent LIM kinase 1 (LIMK1) inhibitor with reported IC50 activity of 22 nM. It inhibits LIMK1-dependent regulation of cofilin phosphorylation and actin cytoskeletal dynamics.

LIMK1 controls actin remodeling downstream of Rho-family GTPase pathways and is involved in cell motility, invasion and morphogenesis. LIMK1 inhibitor BMS4 is useful for studying cytoskeletal signaling and migration-related pharmacology.

Key Features

  • Potent LIMK1 inhibitor
  • Reported IC50: 22 nM
  • Modulates cofilin and actin cytoskeleton regulation
  • Reported to lack off-target cytotoxic effects in source assays

Applications

  • Actin cytoskeleton research
  • Cell migration and invasion assays
  • LIMK/cofilin pathway studies
  • Cancer cell motility pharmacology

More Information

Parent CAS No. 905298-84-2
Chemical Name 1-ethyl-3-(5-(6-(4-methoxy-2,6-dimethylphenyl)-2-(pyrazin-2-yl)pyrimidin-4-yl)thiazol-2-yl)urea
SMILES N(CC)C(NC1=NC=C(C2C=C(C3=C(C)C=C(OC)C=C3C)N=C(C3=NC=CN=C3)N=2)S1)=O
MFCD N.A.
InChi InChI=1S/C23H23N7O2S/c1-5-25-22(31)30-23-27-12-19(33-23)16-10-17(20-13(2)8-15(32-4)9-14(20)3)29-21(28-16)18-11-24-6-7-26-18/h6-12H,5H2,1-4H3,(H2,25,27,30,31)
InChiKey WUCYRTXFXRZKSV-UHFFFAOYSA-N
CID 46192505
Short Description LIMK1 inhibitor

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