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T56-LIMKi
- T5601640
Axon 2721
CAS:
924473-59-6
Purity:
99%
- Soluble in DMSO
- MF: C19H14F3N3O3
- MW: 389.33
Description
T56-LIMKi is an inhibitor of LIMK2. T56-LIMKi efficiently inhibited the growth of NF1-/- MEF, ST88-14, U87, and Panc-1 cells with IC50 values of 30 μM, 18 μM, 7 μM, and 35 μM, respectively. Moreover, T56-LIMKi reduced tumor size and p-cofilin levels in the Panc-1 tumors in vivo. Potential drug for pancreatic cancer, glioma and schwannoma cells.
More Information
| Parent CAS No. | 924473-59-6 |
|---|---|
| Chemical Name | 3-Methyl-N-(3-(3-(trifluoromethyl)phenylcarbamoyl)phenyl)isoxazole-5-carboxamide |
| SMILES | C1C=CC(C(=O)NC2C=CC=C(C(F)(F)F)C=2)=CC=1NC(=O)C1=CC(C)=NO1 |
| MFCD | MFCD08495674 |
| InChi | InChI=1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27) |
| InChiKey | XVOKFRPKSAWELK-UHFFFAOYSA-N |
| CID | 9438169 |
| Short Description | LIMK2 inhibitor |
References
- E Mashiach-Farkash et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
- R Rak et al. Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model. Oncoscience. 2014 Jan 1;1(1):39-48.
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