Blebbistatin, (±)-

Based on 626 reference(s) in Google Scholar 8 10 626

Axon 2718

CAS [674289-55-5]

MF C18H16N2O2
MW 292.33

  • Purity: 99%
  • Soluble in DMSO

Blebbistatin, (±)-

Description

Blebbistatin is a potent and specific inhibitor of the motor functions of class II myosins (IC50 values of 6.47, 3.58, 2.30 and 1.57 μM for inhibiting actin-activated ATPase activities of SmM, NM2a, NM2b and NM2c, respectively). Blebbistatin inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Moreover, Blebbistatin inhibited both the ATPase and gliding motility activities of human platelet nonmuscle myosin II without inhibiting myosin light chain kinase.

KEYWORDS: (±)-Blebbistatin | Myosin II inhibitor | Blebbistatin | CAS [674289-55-5] | ATP | ATPase (myosin) | Inhibitor | Enzymes

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

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