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(±)-Blebbistatin
- Soluble in DMSO
- MF: C18H16N2O2
- MW: 292.33
Description
(±)-Blebbistatin is a potent and specific inhibitor of the motor functions of class II myosins (IC50 values of 6.47, 3.58, 2.30 and 1.57 μM for inhibiting actin-activated ATPase activities of SmM, NM2a, NM2b and NM2c, respectively). (±)-Blebbistatin inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Moreover, Blebbistatin inhibited both the ATPase and gliding motility activities of human platelet nonmuscle myosin II without inhibiting myosin light chain kinase.
Both enantiomers of (±)-Blebbistatin are available as well.
Axon 3074 - (-)-Blebbistatin (Active enantiomer)
Axon 3144 - (+)-Blebbistatin (Negative control)
More Information
| Parent CAS No. | 674289-55-5 |
|---|---|
| Chemical Name | 3a-Hydroxy-6-methyl-1-phenyl-3,3a-dihydro-1H-pyrrolo[2,3-b]quinolin-4(2H)-one |
| SMILES | C1(C)C=C2C(=O)C3(O)CCN(C4C=CC=CC=4)C3=NC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3 |
| InChiKey | LZAXPYOBKSJSEX-UHFFFAOYSA-N |
| CID | 3476986 |
| Short Description | Myosin II inhibitor |
References
- AF Straight et al. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science. 2003 Mar 14;299(5613):1743-7.
- J Limouze et al. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil. 2004;25(4-5):337-41.
- HM Zhang et al. Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2. Biochemistry. 2017 Aug 1.
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