(±)-Blebbistatin is a potent and specific inhibitor of the motor functions of class II myosins (IC50 values of 6.47, 3.58, 2.30 and 1.57 μM for inhibiting actin-activated ATPase activities of SmM, NM2a, NM2b and NM2c, respectively). (±)-Blebbistatin inhibited contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Moreover, Blebbistatin inhibited both the ATPase and gliding motility activities of human platelet nonmuscle myosin II without inhibiting myosin light chain kinase.

Both enantiomers of (±)-Blebbistatin are available as well.
Axon 3074 - (-)-Blebbistatin (Active enantiomer)
Axon 3144 - (+)-Blebbistatin (Negative control)

KEYWORDS: (±)-Blebbistatin | Myosin II inhibitor | Blebbistatin | CAS [674289-55-5] | ATP | ATPase (myosin) | Inhibitor | Enzymes