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CDN1163
- Soluble in DMSO
- MF: C20H20N2O2
- MW: 320.39
Description
CDN1163 is a small molecule allosteric activator of the sarco/endoplasmic reticulum Ca²⁺-ATPase 2 (SERCA2) enzyme. It binds an allosteric site on SERCA2, enhancing ATP effects to shift the enzyme into its active, calcium-transporting conformation. It increases Ca²⁺-ATPase activity, enhancing ER calcium uptake to clear excess cytosolic calcium.
CDN1163 restores cellular calcium homeostasis by pumping cytosolic calcium back into the endoplasmic reticulum. By refilling these depleted stores, it mitigates ER stress, prevents cell death, and protects mitochondrial function. In animal models, this compound reverses insulin resistance, improves hepatic lipid metabolism, and rescues neurons from Parkinsonian neurodegeneration, making it a versatile research probe.
Key Features
- SERCA2 allosteric activator
- Refills ER stores by accelerating cytosolic calcium pumping
- Attenuates ER stress and ER-stress-induced apoptosis
- Improves mitochondrial and metabolic function in preclinical models
Applications
- SERCA and intracellular calcium homeostasis
- Endoplasmic reticulum stress research
- Mitochondrial function and organelle crosstalk
- Diabetes and metabolic-dysfunction models
- Parkinson’s disease and neuroprotection studies
More Information
| Parent CAS No. | 892711-75-0 |
|---|---|
| Chemical Name | 4-Isopropoxy-N-(2-methylquinolin-8-yl)benzamide |
| SMILES | C12C=CC(C)=NC1=C(NC(=O)C1C=CC(OC(C)C)=CC=1)C=CC=2 |
| MFCD | MFCD07177494 |
| InChi | InChI=1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23) |
| InChiKey | GVGVYDCVFBGALZ-UHFFFAOYSA-N |
| CID | 16016585 |
| Short Description | SERCA activator |
References
- S Kang et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98.
- R Dahl. A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg Med Chem. 2017 Jan 1;25(1):53-57.
