MYK-461 - Mavacamten | SAR439152

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2683

CAS [1642288-47-8]

MF C15H19N3O2
MW 273.33

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in 0.1 N NaOH(aq) and DMSO



MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM.

KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin

Size Unit Price Stock
10 mg €135.00 In Stock
50 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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