MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM.

KEYWORDS: MYK-461 | supplier | Myosin inhibitor | MYK461 | MYK 461 | CAS [1642288-47-8] | ATP | ATPase (cardiac specific myosin) | Inhibitor | Enzymes | Sarcomere | HCM | LVOT | Hypertrophic Cardiomyopathy | Left Ventricular Outflow Tract | Myosin