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MYK-461
- Mavacamten - SAR439152
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H19N3O2
- MW: 273.33
Description
MYK-461 is an inhibitor of sarcomere contraction by decreasing the ATPase activity of the cardiac myosin heavy chain (IC50 value 0.3 μM in mouse cardiac myofibrils). Inhibitors of sarcomere contraction may be a valuable therapeutic approach for hypertrophic cardiomyopathy (HCM). Acute reduction in contractility with MYK-461 is sufficient to relieve left ventricular outflow tract (LVOT) obstruction in feline HCM.
More Information
| Parent CAS No. | 1642288-47-8 |
|---|---|
| Chemical Name | (S)-3-Isopropyl-6-(1-phenylethylamino)pyrimidine-2,4(1H,3H)-dione |
| SMILES | C1C=C([C@H](C)NC2=CC(=O)N(C(C)C)C(=O)N2)C=CC=1 |&1:3,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1 |
| InChiKey | RLCLASQCAPXVLM-NSHDSACASA-N |
| CID | 117761397 |
| Short Description | Myosin inhibitor |
References
- EM Green et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.
- JA Stern et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.
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