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ML364
- Soluble in DMSO
- MF: C24H18F3N3O3S2
- MW: 517.54
Description
ML364, a small molecule inhibitor of the deubiquitinase USP2 (IC50 value of 1.1 μM), induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth.
More Information
| Parent CAS No. | 1991986-30-1 |
|---|---|
| Chemical Name | 2-(4-Methylphenylsulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide |
| SMILES | C1(C(NC2=NC(C3C=CC=CC=3)=CS2)=O)C(NS(=O)(=O)C2C=CC(C)=CC=2)=CC(C(F)(F)F)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H18F3N3O3S2/c1-15-7-10-18(11-8-15)35(32,33)30-20-13-17(24(25,26)27)9-12-19(20)22(31)29-23-28-21(14-34-23)16-5-3-2-4-6-16/h2-14,30H,1H3,(H,28,29,31) |
| InChiKey | QZUGMNXETPARLI-UHFFFAOYSA-N |
| CID | 70789348 |
| Short Description | USP2 inhibitor |
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