ML364

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2678

CAS [1991986-30-1]

MF C24H18F3N3O3S2
MW 517.54

  • Purity: 99%
  • Soluble in DMSO
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ML364

Description

ML364, a small molecule inhibitor of the deubiquitinase USP2 (IC50 value of 1.1 μM), induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth.

KEYWORDS: ML364 | supplier | USP2 inhibitor | ML 364 | ML-364 | CAS [1991986-30-1] | Non Selective (Ubiquitin peptides) | Deubiquitinase | Inhibitor | Enzymes

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Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €435.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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