Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2661

CAS [1845753-81-2]

MF C24H23NO3
MW 373.44

  • Purity: 99%
  • Optical purity: 98% e.e.
  • Soluble in 0.1N NaOH (aq) and DMSO



AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates.

KEYWORDS: AZD2716 | supplier | sPLA2 inhibitor | AZD 2716 | AZD-2716 | CAS [1845753-81-2] | Phospholipids | PLA2 | Inhibitor | Enzymes | Coronary Artery Disease

Size Unit Price Stock
5 mg €145.00 In Stock
25 mg €545.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €220.00 In Stock
2 x 25 mg €880.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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