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Axon 2623
CAS [1916571-90-8]
MF C20H23F3N4SMW 408.48
Non-competitive PHGDH inhibitor (IC50 value 2.5 µM) that reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors.
KEYWORDS: NCT-503 | supplier | PHGDH inhibitor | NCT503 | NCT 503 | CAS [1916571-90-8] | 3-phosphoglycerate | 3-PG | serine | cancer | NSCLC | phosphoglycerate dehydrogenase
N-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide
[1916571-90-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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