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CBR 5884

Axon 2585
CAS:  681159-27-3
Purity:  99%
  • Soluble in DMSO
  • MF:  C14H12N2O4S2
  • MW:  336.39

Description

CBR 5884 is a noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH; IC50 value 33 µM) with selective toxicity towards cancer cell lines with high serine biosynthetic activity. CBR-5884 shows no inhibitory effect on two other NAD+-dependent dehydrogenases, lactate dehydrogenase (LDH) and MDH1A.

PHGDH pharmacology is highly relevant to cancer and metabolic reprogramming research; CBR-5884 serves as a potent small-molecule tool that supports mechanistic studies of PHGDH and serine biosynthesis across biochemical, cellular, and disease-model assays.

Key Features

  • Non-competitive PHGDH inhibitor
  • IC50 value: 33 µM
  • Modulates PHGDH-dependent biological activity
  • No LDH and MDH1A inhibition

Applications

  • PHGDH pharmacology and target-validation studies
  • Disease-model research related to cancer
  • Compound profiling, assay development and lead-optimization support

More Information

Parent CAS No. 681159-27-3
Chemical Name ethyl 5-(furan-2-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
SMILES C1(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C(SC#N)C=1C
MFCD N.A.
InChi InChI=1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
InChiKey QBVIRPJBDIZKBC-UHFFFAOYSA-N
CID 4674993
Short Description PHGDH inhibitor

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