Enhancer of CRISPR-based genome editing and homology-directed repair (HDR; RAD51). RS-1 can enhance filament stability, and stimulated hRAD51-mediated homologous strand assimilation (D-loop) activity by at least 5- to 11-fold. RS-1 acts as an allosteric regulator that locks hRAD51 in an active conformation and does so without influencing the active site for ATP hydrolysis. Treatment with RS-1 promoted significant antitumor responses in a mouse model.

KEYWORDS: RS-1 | supplier | RAD51 stimulator | RAD51-Stimulatory Compound-1 | RS1 | CAS [312756-74-4] | DNA-RNA | RAD51 | Stimulator | CRISPR | genome editing | homology-directed repair | HDR | filaments | Cas9