PXS 4728A - PXS 4728 HCl

Based on 17 reference(s) in Google Scholar 9 10 17

Axon 2583

CAS [1478364-68-9]

MF C15H21FN2O2.HCl
MW 316.80

  • Purity: 98%
  • Soluble in water and DMSO

PXS 4728A

Description

Potent and orally available inhibitor of VAP-1 (aka SSAO/AOC3; IC50 value 5 nM), inhibiting neutrophil rolling and tethering in the mouse cremaster model, and showing >500-fold selectivity for VAP-1/SSAO over all the related human amine oxidases. PXS 4728 diminishes lung inflammation in a variety of models indicating proof of concept for a novel therapeutic approach in respiratory diseases that are characterized by neutrophilic pattern of inflammation. PXS 4728 is in clinical trials for the treatment of cardiometabolic diseases like the liver-related disease Nonalcoholic Steatohepatitis (NASH).

KEYWORDS: PXS 4728A | supplier | VAP-1/SSAO inhibitor | PXS 4728 HCl | PXS4728 | supplier | CAS [1478364-68-9] | [1478364-40-7] | Mono-amines | VAP | Inhibitor | SSAO | AOC3 | neutrophil | vascular | adhesion molecules | SSAO/VAP-1 | lung inflammation | COPD | airway | respiratory | steatohepatitis | NASH | liver disease | Semicarbazide Sensitive Amine Oxidase

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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