Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 µM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract.

KEYWORDS: Eact | supplier | TMEM16A activator | CAS [461000-66-8] | Chloride | ANO1 | calcium activated chloride channel | CaCC | Ion Channel | rectifying current | secretion | cystic fibrosis | CF | dry | motility disorder | gastrointestinal tract