Potent and specific Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 protects against loss of dopamine neurons in the substantia nigra as well as dopamine terminals in the striatum in MPTP-induced mouse models for Parkinson's disease.

KEYWORDS: C-DIM12 | supplier | Nurr1 activator | DIM-C-pPhCl | CDIM12 | C-DIM 12 | CAS [178946-89-9] | Intracellular Transcription Factors | NURR | Activator | Nuclear Receptors | NR4A2 | inflammation | CNS | dopaminergic | neurons | NF-κB | ganglia | Parkinson's