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DY 268
- Soluble in DMSO
- MF: C30H32N4O5S
- MW: 560.66
Description
Highly potent FXR antagonist with a promising in vitro profile (IC50 values 7.5 nM and 468.5 nM in FXR binding assay and cell-based FXR antagonistic assay, respectively). DY 268 shows no FXR agonistic activity nor cytotoxicity, making it an excellent chemical tool to elucidate the biological function of FXR.
More Information
| Parent CAS No. | 1609564-75-1 |
|---|---|
| Chemical Name | 1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-p-tolyl-1H-pyrazole-4-carboxamide |
| SMILES | N1(CC2=CC=CC(OC)=C2)C=C(C(NC2=CC=C(C)C(S(N3CCOCC3)(=O)=O)=C2)=O)C(C2=CC=C(C)C=C2)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H32N4O5S/c1-21-7-10-24(11-8-21)29-27(20-33(32-29)19-23-5-4-6-26(17-23)38-3)30(35)31-25-12-9-22(2)28(18-25)40(36,37)34-13-15-39-16-14-34/h4-12,17-18,20H,13-16,19H2,1-3H3,(H,31,35) |
| InChiKey | KQSPAAPFKIEUGH-UHFFFAOYSA-N |
| CID | 90656831 |
| Short Description | FXR antagonist |
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