PF 06260933 dihydrochloride

Based on 3 publications in PubMed 9 10 3

Axon 2545

CAS [N.A.]

MF C16H13ClN4.2HCl
MW 369.68

  • Purity: 99%
  • Soluble in water and DMSO

PF 06260933 dihydrochloride

Description

Potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis. Robustly prevented TNF-α-mediated endothelial permeability in vitro, similar to MAP4K4 knockdown, and without alteration of plasma lipid content.

KEYWORDS: PF 06260933 dihydrochloride | supplier | MAP4K4 inhibitor | PF06260933 | CAS [1811510-56-1] | MAPK | MAP4K | Inhibitor | HGK | ZC1 | mitogen activated | endothelial | diabetes | vascular inflammation | atherosclerosis | TNF | NF-κB

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5 mg €85.00 In Stock
25 mg €325.00 In Stock
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2 x 5 mg €140.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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