OSU 03012

Based on 238 publications in PubMed 10 10 238

Axon 2525

CAS [742112-33-0]

MF C26H19F3N4O
MW 460.45

  • Purity: 99%
  • Soluble in DMSO

OSU 03012

Description

ATP competitive PDK-1 inhibitor (IC50 value 5 μM for both PDK-1/PDPK1) that inhibits the growth of thyroid, prostate and breast cancer xenografts in vivo. A Celecoxib (Axon 1919) derivative that inhibits PAK phosphorylation and cell proliferation with reduced Akt phosphorylation by PDK1, without inhibition of cycloogygenases. Moreover, overexpression of constitutively active forms of PDK-1 and Akt partially protected OSU-03012-induced apoptosis.

KEYWORDS: OSU 03012 | supplier | PDK-1 inhibitor | OSU03012 | CAS [742112-33-0] | Phosphatidylinositol | PDPK | PAK | Akt | apoptosis | prostate | breast | thyroid | cancer | proliferation | p70S6 | p21 | PKC

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10 mg €95.00 In Stock
50 mg €350.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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