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CM1
- Soluble in water and DMSO
- MF: C14H22N2O3
- MW: 266.34
Description
Orally active iron chelator with high affinity and selectivity for iron(III) (relative metal complex stability constants of pFe(III)= 20.3; pCu(II)= 9.8; pZn(II)= 6.2) and a suit-able partition coefficient to permeate membranes. CM1 is able to penetrate hepatocytes and relatively non toxic. Potential therapeutic for patients suffering from thalassaemia related iron overload Moreover, CM1 shows an inhibitory effect on the growth of Plasmodium falciparum (malaria parrasite; IC50 value 35 µM).
More Information
| Parent CAS No. | 1643659-63-5 |
|---|---|
| Chemical Name | N-(6-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)hexyl)acetamide |
| SMILES | C(NCCCCCCN1C(C)=C(O)C(=O)C=C1)(=O)C |
| MFCD | N.A. |
| InChi | InChI=1S/C14H22N2O3/c1-11-14(19)13(18)7-10-16(11)9-6-4-3-5-8-15-12(2)17/h7,10,19H,3-6,8-9H2,1-2H3,(H,15,17) |
| InChiKey | AUVGDBMRJYKPEA-UHFFFAOYSA-N |
| CID | 117072346 |
| Short Description | Iron chelator |
References
- K. Pangjit et al. Characterisation of a novel oral iron chelator: 1-(N-Acetyl-6-Aminohexyl)-3-Hydroxy-2-Methylpyridin-4-one. J Pharm Pharmacol. 2015 May;67(5):703-13.
- N. Chansiw et al. Effect of a novel oral active iron chelator: 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in iron-overloaded and non-overloaded mice. Asian Pac J Trop Med. 2014 Sep;7S1:S155-61.
- P. Thipubon et al. Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum. Malar J. 2015 Sep 30;14:382.
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