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WDR5-0103
Axon 2411
CAS:
890190-22-4
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H25N3O4
- MW: 383.44
Description
Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL (Kd value 0.45 µM for WDR5 binding, and IC50 value of 39 μM for inhibition of methyltransferase activity of MLL complex). Potential therapeutic for treatment of MLL-rearranged leukemias or other cancers.
More Information
| Parent CAS No. | 890190-22-4 |
|---|---|
| Chemical Name | methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate |
| SMILES | C(OC)(=O)C1=CC=C(N2CCN(C)CC2)C(NC(=O)C2=CC=CC(OC)=C2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H25N3O4/c1-23-9-11-24(12-10-23)19-8-7-16(21(26)28-3)14-18(19)22-20(25)15-5-4-6-17(13-15)27-2/h4-8,13-14H,9-12H2,1-3H3,(H,22,25) |
| InChiKey | ZPLBXOVTSNRBFB-UHFFFAOYSA-N |
| CID | 6457069 |
| Short Description | WDR5 inhibitor |
References
- G. Senisterra et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-9.
- Y. Bolshan et al. Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett. 2013 Feb 4;4(3):353-7.
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