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OICR-9429
Axon 3583
CAS:
1801787-56-3
Purity:
98%
- Soluble in 0.1N NaOH(aq), 0.1N HCl(aq) and DMSO
- MF: C29H32F3N5O3
- MW: 555.59
Description
OICR-9429 is a first-in-class, potent, highly selective and cell-active antagonist of the Wdr5-MLL interaction, which is able to elicit a profound disruption of the protein-protein interaction network around Wdr5 and the SET/ MLL HMT complex. OICR-9429 binds to WDR5 with high affinity (KD value of 93 nM).
More Information
| Parent CAS No. | 1801787-56-3 |
|---|---|
| Chemical Name | N-(4-(4-Methylpiperazin-1-yl)-3'-(morpholinomethyl)biphenyl-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide |
| SMILES | C1C(NC(=O)C2C(C(F)(F)F)=CC(=O)NC=2)=C(N2CCN(C)CC2)C=CC=1C1C=CC=C(CN2CCOCC2)C=1 |
| MFCD | MFCD28411621 |
| InChi | InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39) |
| InChiKey | DJOVLOYCGXNVPI-UHFFFAOYSA-N |
| CID | 91623360 |
| Short Description | Wdr5-MLL antagonist |
References
- F Grebien et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-578.
- M Getlik et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96.
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