WDR5

The WD40 protein WDR5 is a core subunit of the human MLL and SET1 (hCOMPASS) histone H3 Lys4 (H3K4) methyltransferase complexes[1]. WDR5 consists of 334 amino acids and contains seven typical WD40 repeat domains, each approximately 40 amino acids, adopting a seven-bladed beta-propeller fold. It has been proposed that WDR5 is the component of the MLL complex that interacts directly with dimethylated H3K4 and is required for transition to trimethylation by the MLL complex. More recently, however, It has been demonstrated that yeast CPS30 and its mammalian homolog, WDR5, are required for complex assembly and that no H3K4 methylation is observed in their absence, indicating that WDR5 is central for complex assembly and activity. WDR5 plays important roles in developmental events, transcriptional regulation, and leukemogenesis[2]. Interestingly, it has been revealed that WDR5 was not only localized in the nucleus, but also abundantly localized in the cytoplasm, and hypothesized to play a role in  viral infections[3].


[1] R.C. Trievel et al. WDR5, a complexed protein. Nat Struct Mol Biol. 2009 Jul;16(7):678-80.
[2] M. Wu et al. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer. 2011 Apr; 30(4): 240–246.
[3] Y Y. Wang et al. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):815-20.

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Axon ID Name Description From price
2411 WDR5-0103 Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL €90.00

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