GNE 7915

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2348

CAS [1351761-44-8]

MF C19H21F4N5O3
MW 443.40

  • Purity: 99%
  • Soluble in DMSO

GNE 7915


Highly potent, selective, metabolically stable, and brain-penetrable LRRK2 inhibitor (IC50 value 9 nM for phospho-LRRK2 in vitro). GNE 7915 is selective across 187 screened kinases, and >3200 and 53 times selective over JAK2 and TTK, respectively. GNE 7915 does not suppress LPS-stimulated TNFα and CXCL10 levels in LPS-treated primary wild-type (WT) or knockout (KO) astrocyte cultures, and is not reported to cause cellular or genetic toxicity.

Size Unit Price Stock
10 mg €110.00 In Stock
50 mg €360.00 In Stock
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Size Unit Price Stock
2 x 10 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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