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PF 06447475
Axon 2546
CAS:
1527473-33-1
Purity:
99%
- Soluble in DMSO
- MF: C17H15N5O
- MW: 305.33
Description
Highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor (IC50 value 3 nM); an exceptional tool compound to study the function of LRRK2 PF 06447475 mitigates both neurodegeneration and neuroinflammation associated with G2019S-LRRK2 expression by LRRK2 kinase inhibition in rats.
More Information
| Parent CAS No. | 1527473-33-1 |
|---|---|
| Chemical Name | 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile |
| extra_info | . |
| SMILES | C(#N)C1=CC=CC(C2C3=C(N4CCOCC4)N=CN=C3NC=2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21) |
| InChiKey | BHTWDJBVZQBRKP-UHFFFAOYSA-N |
| CID | 72706840 |
| Short Description | LRRK2 inhibitor |
References
- J.L. Henderson et al. Discovery and preclinical profiling of PF-06447475, a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32.
- J.P. Daher et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J Biol Chem. 2015 Aug 7;290(32):19433-44.
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