Potent Mer kinase inhibitor (in vitro IC50 values 1.7 nM, 270 nM, and 100 nM for Mer, Axl, and Tyro3 RTKs, respectively) with promising selectivity and PK properties. UNC 2250 efficiently inhibited both steady state and ligand-stimulated phosphorylation of Mer, and confirmed functional antitumor activity by exhibiting potential to reduced colony-forming in both rhabdoid tumor cells and NSCLC cells.

KEYWORDS: UNC2250 | supplier | Mer Inhibitor | UNC-2250 | UNC 2250 | CAS [1493694-70-4] | Gas6 | Mer | TAM | RTK | Axl | Tyro3 | antitumor | rhabdoid | NSCLC | lung cancer