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UNC569
Axon 2086
CAS:
1350547-65-7
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C22H29FN6
- MW: 396.5
Description
UNC569 is a potent, reversible and ATP-competitive Mer receptor tyrosine kinase (MerTK/MERTK) inhibitor with reported IC50 activity of 2.9 nM. It inhibits Mer activation and downstream ERK1/2 and AKT signaling.
MerTK is a TAM-family receptor involved in efferocytosis, survival signaling, immune regulation and cancer progression. UNC569 is useful for studying Mer-dependent signaling in leukemia, brain tumor and immune-oncology models.
Key Features
- Potent MerTK inhibitor
- Reported IC50: 2.9 nM
- Reversible ATP-competitive inhibition mechanism
- Blocks Mer-driven ERK1/2 and AKT signaling
Applications
- MerTK kinase assays
- TAM receptor signaling studies
- Leukemia and brain tumor models
- Immune-oncology pathway research
More Information
| Parent CAS No. | 1350547-65-7 |
|---|---|
| Chemical Name | 1-((4-aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine |
| MFCD | N.A. |
| Short Description | Mer Inhibitor |
References
- S Christoph et al. UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol. Cancer Ther. 2013, Aug 30, [Epub ahead of print].
- J Liu et al. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. Med. Chem. Lett. 2012, 3, 129-134.
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