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DDR1-IN-1
Axon 2265
CAS:
1449685-96-4
Purity:
98%
- Soluble in DMSO
- MF: C30H31F3N4O3
- MW: 552.59
Description
Potent and selective DDR1 receptor tyrosine kinase (RTK) inhibitor (IC50 values 105 and 413 nM for DDR1 and DDR2 respectively); a useful pharmacological probe for DDR1-dependent signal transduction.
More Information
| Parent CAS No. | 1449685-96-4 |
|---|---|
| Chemical Name | 4-((4-Ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-(2-oxoindolin-5-yloxy)phenyl)-3-(trifluoromethyl)benzamide |
| SMILES | C12NC(=O)CC=1C=C(OC1C(C)=CC=C(NC(=O)C3C=C(C(F)(F)F)C(CN4CCN(CC)CC4)=CC=3)C=1)C=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H31F3N4O3/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38) |
| InChiKey | AOZPVMOOEJAZGK-UHFFFAOYSA-N |
| CID | 72836888 |
| Short Description | DDR1 inhibitor |
References
- H.G. Kim et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. A.C.S. Chem. Biol. 2014, 9, 840.
- P. Canning et al. Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. J. Mol. Biol. 2014, 426, 2457-2470.
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