LDK 378 - Ceritinib

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2224

CAS [1032900-25-6]

MF C28H36ClN5O3S
MW 558.14

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

LDK 378

Description

Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models.

J. Chen et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J. Med. Chem. 2013, 56, 5673-5674.

T.H. Marsilje et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(...). J. Med. Chem. 2013, 56, 5675-5690.

E. Ardini et al. ALK Inhibitors, a Pharmaceutical Perspective. Front Oncol. 2012, 2, 17.

Cell Signaling & Oncology ALK TGF-β RTK class XIX; 2.7.10.1

Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor

Chemical name

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

Parent CAS No.

[1032900-25-6]

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Size	Unit Price	Stock
5 mg	€95.00	In Stock
25 mg	€285.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock
2 x 25 mg	€420.00	In Stock

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2267	GSK 1838705A	Potent IGF-IR and insulin receptor (IR) kinase inhibitor with additional affinity for ALK	€110.00
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LDK 378 - Ceritinib

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LDK 378 - Ceritinib

Description

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