AR 244555

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2191

CAS [858350-62-6]

MF C23H23ClF2N2O
MW 416.89

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

AR 244555

Description

Inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively). AR 244555 caused a dose-dependent inhibition of inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells, and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes.AR 244555 caused a modest but significant increase in coronary flow in rat hearts witout causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion.
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5 mg €140.00 In Stock
25 mg €500.00 In Stock
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2 x 5 mg €220.00 In Stock
2 x 25 mg €800.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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