AZD3463

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2153

CAS [1356962-20-3]

MF C24H25ClN6O
MW 448.95

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

AZD3463

Description

Potent inhibitor of Anaplastic Lymphoma Kinase (ALK) and IGF1R; AZD3463 is potent in ALK-driven preclinical models and in a variety of crizotinib-resistant models

Y Wang et al. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016 Jan 20;6:19423.

Concurrent roles for IGF1R and EGFR in driving acquired resistance to crizotinib and ability to overcome with a combination of the ALK/IGF1R inhibitor AZD3463 and Iressa. Abstr. 4465 presented by L Drew et al. AACR Annual Meeting 2013 Washington DC USA.

Cell Signaling & Oncology ALK Endocrinology TGF-β RTK class II and XIX; EC 2.7.10.1

Potent inhibitor of ALK and IGF1R

Chemical name

N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine

Parent CAS No.

[1356962-20-3]

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Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€405.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€600.00	In Stock

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