PX 20350 - FXR agonist Cpd 22

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2152

CAS [1198085-23-2]

MF C28H22Cl2F3N3O4
MW 592.39

Purity: 99%
Soluble in DMSO

PX 20350

Description

Potent farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FXR direct reporter (DR) assay (6 nM vs 30 nM for GW 4064). Cpd 22 showed a linear dose-dependent reduction in total plasma triglycerides and total plasma cholesterol.

U. Abel et al. Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. Bioorg. Med. Chem. Lett. 2010, 20, 4911–4917.

U. Deuschle et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012, 7, e43044.

Potent farnesoid X receptor (FXR) agonist

Chemical name

4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)(methyl)amino)methyl)benzoic acid

Parent CAS No.

[1198085-23-2]

Order

Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€365.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1266	GW 3965 hydrochloride	Liver X receptor agonist		€95.00
1749	WAY 362450	Farnesoid X receptor (FXR) agonist		€125.00
1991	WYE 672	Liver X receptor (LXR) agonist		€120.00
2357	LXR 623	Partial agonist of Liver X Receptor		€95.00
2363	GSK 2033	The first potent cell-active LXR antagonist		€105.00
2598	SR 9243	LXR inverse agonist inhibiting the Warburg effect and lipogenesis in cancer cells		€85.00
2561	DY 268	Highly potent FXR antagonist with a promising in vitro profile		€120.00
2657	MGL-3196	Oral, liver-targeted, selective thyroid hormone receptor β-agonist		€90.00
3174	Obeticholic acid	Potent and selective FXR agonist		€60.00
4256	Fexaramine	Highly potent and highly selective FXR agonist	Recently added	€125.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

PX 20350 - FXR agonist Cpd 22

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

PX 20350 - FXR agonist Cpd 22

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us