Bulk Inquiry
BD 1063 dihydrochloride
Axon 2088
- Parent CAS: 150208-28-9
Purity:
98%
- Soluble in water and DMSO
- MF: C13H18Cl2N2.2HCl
- MW: 346.12
Description
Potent and selective sigma-1 (σ-1) receptor antagonist (Ki=9 nM); about 50-fold more selective for sigma-1 over sigma-2 and >100-fold more selective over 9 other tested neurotransmitter receptors; shown to antagonize cocaine efffects
More Information
| Parent CAS No. | 150208-28-9 |
|---|---|
| Chemical Name | 1-(3,4-dichlorophenethyl)-4-methylpiperazine dihydrochloride |
| SMILES | N1(CCC2=CC=C(Cl)C(Cl)=C2)CCN(C)CC1.Cl.Cl |
| MFCD | MFCD00792740 |
| InChi | InChI=1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H |
| InChiKey | NXFDBTLQOARIMH-UHFFFAOYSA-N |
| CID | 11617161 |
| Short Description | Sigma-1 antagonist |
References
- V Sabino et al. The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking. Neuropsychopharmacology 34.6 (2008): 1482-1493.
- KA McCracken et al. Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur. J. Pharmacol. 1995, 365(1), 35-38.
- FP Monnet et al. Neurosteroids, via sigma receptors, modulate the [3H] norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc. Nat. Acad. Sci. 1995, 92(9), 3774-3778.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1215 | BD 1047 dihydrobromide |
From $82.50 |
| 1272 | PB28 dihydrochloride |
From $104.50 |
| 1767 | SA 4503 |
From $132.00 |
| 2919 | 4-IBP |
From $99.00 |
| 3063 | PRE-084 hydrochloride |
From $82.50 |
Other Categories
Get a Quote for
Loading...