Bulk Inquiry
Eletriptan hydrobromide
- UK 116044-04
- Parent CAS: 143322-58-1
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C22H26N2O2S.HBr
- MW: 463.43
Description
Eletriptan hydrobromide is a potent and selective serotonin 5-HT1B/5-HT1D receptor agonist. It belongs to the triptan class and activates receptor pathways involved in cranial vasoconstriction and trigeminal neurotransmission.
5-HT1B/1D receptors are key pharmacological targets in migraine research because they modulate cranial vascular tone and neuropeptide release. Eletriptan is useful for studying triptan mechanism-of-action and serotonergic migraine pharmacology.
Key Features
- Selective 5-HT1B/5-HT1D receptor agonist
- Triptan-class antimigraine pharmacology
- Modulates cranial vascular and trigeminal signaling
- Useful serotonergic GPCR tool
Applications
- 5-HT1B/1D receptor assays
- Migraine mechanism research
- Trigeminal neurotransmission studies
- Serotonergic GPCR profiling
More Information
| Parent CAS No. | 143322-58-1 |
|---|---|
| Chemical Name | (R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole hydrobromide |
| extra_info | . |
| SMILES | N1C2=C(C=C(CCS(C3=CC=CC=C3)(=O)=O)C=C2)C(C[C@H]2CCCN2C)=C1.Br |&1:20,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H26N2O2S.BrH/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20;/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3;1H/t19-;/m1./s1 |
| InChiKey | UTINOWOSWSPFLJ-FSRHSHDFSA-N |
| CID | 656631 |
| Short Description | 5-HT1B/1D agonist |
References
- P Gupta et al. The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur. J. Pharmacol. 2000, 398(1), 73-81.
- PJ Goadsby et al. Eletriptan in acute migraine - A double-blind, placebo-controlled comparison to sumatriptan. Neurology 2000, 54(1), 156.
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