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GSK2334470
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H34N8O
- MW: 462.59
Description
GSK2334470 is a potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor with an IC50 value of ~10 nM. GSK2334470 does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations.
More Information
| Parent CAS No. | 1227911-45-6 |
|---|---|
| Chemical Name | (3S,6R)-1-(6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-N-cyclohexyl-6-methylpiperidine-3-carboxamide |
| SMILES | C1CC(NC([C@H]2CC[C@@H](C)N(C3C=C(C4C=CC5C(N)=NNC=5C=4)N=C(NC)N=3)C2)=O)CCC1 |&1:5,8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1 |
| InChiKey | QLPHOXTXAKOFMU-WBVHZDCISA-N |
| CID | 46215815 |
| Short Description | PDK1 inhibitor |
References
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