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SB 747651A

 - SB 747651 tetrahydrochloride
Axon 1897
  • Parent CAS:  607372-46-3
Purity:  98%
  • Soluble in water and DMSO
  • MF:  C16H22N8O.4HCl
  • MW:  488.24

Description

SB 747651A is a potent mitogen- and stress-activated kinase 1 (MSK1) inhibitor with a reported IC50 value of 11 nM in vitro.

MSK1 acts downstream of ERK and p38 MAPK signaling to regulate transcription factors and chromatin marks such as CREB and histone H3 phosphorylation. SB 747651A is useful for studying MSK-dependent transcriptional responses.

Key Features

  • Potent MSK1 inhibitor
  • In vitro IC50: 11 nM
  • Inhibits cellular MSK activity at micromolar concentrations
  • Improved selectivity compared with older kinase inhibitors such as H89 and Ro 31-8220

Applications

  • MSK1 kinase pharmacology
  • ERK/p38 downstream transcriptional signaling studies
  • CREB and histone H3 phosphorylation assays
  • MAPK-responsive gene-expression research

More Information

Certificate of Analysis (B2)
Material Safety Data Sheet (B2)

Certificate of Analysis

B1

Material Safety Data Sheet

B1
Parent CAS No. 607372-46-3
Chemical Name 4-(1-ethyl-7-((piperidin-4-ylamino)methyl)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine tetrahydrochloride
SMILES C1=NC=C(CNC2CCNCC2)C2N(CC)C(C3C(N)=NON=3)=NC1=2.Cl.Cl.Cl.Cl
MFCD N.A.
InChi InChI=1S/C16H22N8O.4ClH/c1-2-24-14-10(8-20-11-3-5-18-6-4-11)7-19-9-12(14)21-16(24)13-15(17)23-25-22-13;;;;/h7,9,11,18,20H,2-6,8H2,1H3,(H2,17,23);4*1H
InChiKey JBYSIGKTZDYOGF-UHFFFAOYSA-N
CID 91826488
Short Description MSK1 inhibitor

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