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Apixaban
- BMS 562247-01
Axon 1754
CAS:
503612-47-3
Purity:
98%
- Soluble in DMSO
- MF: C25H25N5O4
- MW: 459.5
Description
Apixaban is a direct, reversible factor Xa inhibitor with anticoagulant pharmacology.
Factor Xa links intrinsic and extrinsic coagulation pathways to thrombin generation. Apixaban is a clinically validated reference inhibitor for studying coagulation cascade pharmacology, FXa selectivity and anticoagulant mechanisms.
Key Features
- Direct inhibitor of coagulation factor Xa
- Blocks thrombin generation upstream in the coagulation cascade
- Clinically validated anticoagulant mechanism
- Useful reference compound for hemostasis research
Applications
- Factor Xa enzyme assays
- Coagulation cascade research
- Anticoagulant mechanism studies
- Thrombosis and hemostasis models
More Information
| Parent CAS No. | 503612-47-3 |
|---|---|
| Chemical Name | 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| SMILES | C12C(C(N)=O)=NN(C3C=CC(OC)=CC=3)C=1C(=O)N(C1C=CC(N3CCCCC3=O)=CC=1)CC2 |
| MFCD | MFCD11977295 |
| InChi | InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) |
| InChiKey | QNZCBYKSOIHPEH-UHFFFAOYSA-N |
| CID | 10182969 |
| Short Description | Factor Xa inhibitor |
References
- CB Grange et al. Apixaban versus Warfarin in Patients with Atrial Fibrillation. N. Engl. J. Med. 2011, 365, 981-992.
- JH Alexander et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N. Engl. J. Med. 2011, 365(8), 699-708.
- SJ Connolly et al. Apixaban in patients with atrial fibrillation. N. Engl. J. Med. 2011, 364(9), 806–817.
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